We use cookies from third party services for marketing activities and to offer you a better experience. Read about how we use cookies and how you can control them by clicking "Privacy Preferences".

Privacy Preferences

When you visit any website, it may store or retrieve information through your browser, usually in the form of cookies. Since we respect your right to privacy, you can choose not to permit data collection from certain types of services. However, not allowing these services may impact your experience.

  • Privacy Policy
    When you visit any of our websites, it may store or retrieve information on your browser, mostly in the form of cookies. This information might be about you, your preferences or your device and is mostly used to make the site work as you expect it to. The information does not usually directly identify you, but it can give you a more personalized web experience. Because we respect your right to privacy, you can choose not to allow some types of cookies. Click on the different category headings to find out more and manage your preferences. Please note, blocking some types of cookies may impact your experience of the site and the services we are able to offer.
  • Content Delivery Network
    These cookies enable the website to provide enhanced functionality and personalization. They may be set by us or by third party providers whose services we have added to our pages. If you do not allow these cookies then some or all of these services may not function properly.
  • Functional (Your preferences for this site)
    Functionality cookies allow websites to remember the user's site preferences and choices they make on the site including username, region, and language. This allows the website to provide personalized features like local news stories and weather if you share your location. They are anonymous and don't track browsing activity across other websites. Functionality cookies can include first party, third party, persistent or session cookies.
  • Statistics (Info on how we can get better)
    These cookies allow us to count visits and traffic sources so we can measure and improve the performance of our site. They help us to know which pages are the most and least popular and see how visitors move around the site, which helps us optimize your experience. All information these cookies collect is aggregated and therefore anonymous. If you do not allow these cookies we will not be able to use your data in this way.
  • Marketing (Advertisement Delivery Network)
    These cookies may be set through our site by our advertising partners. They may be used by those companies to build a profile of your interests and show you relevant adverts on other sites. They do not store directly personal information but are based on uniquely identifying your browser and internet device. If you do not allow these cookies, you will experience less targeted advertising.

Privacy policy




Our developments date back to 2007, when the first indications of our LDL-lowering technology were discovered. The following years have been subject to several research endeavors, partnered with leading academic and research institutes. Throughout, we developed a strong patent lineage, with very recent patent filings to ensure an endured asset value. The high potency of our technology as well as the high selectivity for LDL-cholesterol, leaving the ‘good’ HDL cholesterol levels unaffected, were validated in many different in vivo models. These findings indicate the potential of a next-generation cholesterol lowering functional food ingredients and nutraceuticals.

Another application is in feed materials. 

The previous paragraph describes R. rubrum as a direct beneficial supplement to reduce human blood cholesterol. As cholesterol levels are influenced both by liver synthesis and dietary intake, focus can also be diverted to a reduced intake of cholesterol-containing products. A well-known source of animal cholesterol is found in egg yolks. The Netherlands Nutrition Centre recommends a weekly consumption of only 2-3 eggs because of its cholesterol contents. Therefore, eggs are perceived as a major source of dietary cholesterol intake. 

The cholesterol-lowering effects of R. rubrum in hens was already apparent from figure 5. As such, SEMILLA Health investigated the downstream effects on the cholesterol content of laying-hen eggs. As indicated by table 1, R. rubrum addition to poultry feed during several weeks, led to egg production with a reduced cholesterol content.

In 2017 these findings were incorporated into SEMiLLA Health BV. New developments were initiated from 2020 based on new intellectual property, including compounds that have shown promising beneficial effects in non-alcoholic fatty liver disease (NAFLD - NASH) and atherosclerosis in preclinical studies. Subsuequent compound assessments are plannend also on non-CVD/non-metabolic diseases.

Back to page